Efficacy

Verifying the efficacy of your lead molecules is of crucial
importance prior to investing further on the lead optimization.

Disease models help you to select molecules with
a therapeutic potential for drug development.

 

Animal models of diabetes and obesity

(Factsheet)

The effects of test item(s) and different diets on type 2 diabetes and obesity can be easily studied in rodent models.

MADE services include the following diabetes/obesity animal models:

The Zucker Diabetic Sprague Dawley rat (ZDSD)

  • type 2 diabetes
  • resembles the human condition better than other rodent models

Goto-Kakizaki rat (GK)

  • a non-obese model of type 2 diabetes
  • mild hyperglycemia
  • hyperinsulinemia
  • insulin resistance
  • osteopathy

Zucker Diabetic Fatty rat (ZDF)

  • a mutation in the leptin receptor (Leprfa)
  • type 2 diabetes and related complications

Diet induced obesity

  • eg. SD rat exposed to a high-energy diet

Animal models of hypertension

High blood pressure, also known as hypertension, is the single most important risk factor for stroke.

MADE services include the following stroke and hypertension animal models:

SHRSP   (Factsheet)

  • a spontaneous stroke model

SHR, Dahl/SS   (Factsheet)

  • hypertension
  • insulin resistance
  • hyperinsulinemia
  • hypertriglyceridemia
  • hypercholesterolemia
  • nephropathy

LDL-receptor deficient mice   (Factsheet)

  • hypertriglyceridemia
  • hypercholesterolemia

Animal models of oncology

DMBA induced breast cancer   (Factsheet)

Xenograft models   (Factsheet)

Gastro-intestinal research

Evaluation of anti-Ulcer activity of test Item   (Factsheet)

Rat model for evaluating whether the test item prevents the development or promotes the healing of stomach tissue ulcers.

Evaluation of gastric mucosal damage following test item administration – GI irritation test   (Factsheet)

Because most drugs must bypass the GI tract in order to be absorbed, they are capable of causing stomach irritation, diarrhea, nausea and other GI symptoms. Stomach lesions, such as ulcerations and inflammations, are relatively common side effects of drugs.

Colitis animal model   (Factsheet)

  • Ulcerative Colitis (UC)
  • Crohn´s Disease (CD)

Our validated DSS-induced mouse IBD-models are excellent for screening and testing efficacy of new drugs and formulations for IBD.

Animal models of dermatology  

Acute or chronic skin inflammation   (Factsheet)

12-O-tetradecanoylphorbol-13-acetate (TPA) applied on mouse ear is able to induce an acute inflammatory reaction with erythema, edema and leucocyte infiltration. Repeated applications of TPA leads to prolonged inflammatory reaction with increase in ear weight, epidermal hyperplasia, resembling psoriatic condition.

Animal models of hematology  

Tail-bleeding test using NMRI mice

Animal model for evaluating the test item’s effect on blood clotting.